abstract：:The clinical profile of Org OD 14 ((7 alpha,17 alpha)-17-hydroxy-7-methyl-19-norpregn-5 (10)-en-20-yn-3-one) is remarkable in that the compound demonstrates simultaneous weak oestrogenic, androgenic and progestational activity after oral administration to animals. It was therefore studied to evaluate its efficacy in t...

journal_title：Maturitas

authors： Tax L,Goorissen EM,Kicovic PM

更新日期：1987-01-01 00:00:00

abstract：:Most therapy for osteoporosis has been aimed at decreasing bone resorption and is capable of preventing further bone loss. Recently, anabolic steroids have been claimed to cause increased bone mass in osteoporosis, but the mechanism for this effect is not understood. In this study calcium, and calcium with calcitriol,...

journal_title：Maturitas

authors： Need AG,Chatterton BE,Walker CJ,Steurer TA,Horowitz M,Nordin BE

更新日期：1986-12-01 00:00:00

abstract：:The aim of this trial was to study the vaginal absorption of oestriol and to investigate whether morning rather than evening oestriol administration would produce different plasma oestriol patterns. The influence of food intake on plasma oestriol levels was also investigated. Nine post-menopausal women were given 0.5 ...

journal_title：Maturitas

authors： Heimer GM,Englund DE

更新日期：1986-10-01 00:00:00

abstract：:The incidence of breast cancer has continued to decrease each year at Wilford Hall United States Air Force Medical Center with the ever-increasing use of combined progestogen-oestrogen replacement therapy over the past 12 yr. By 1983, the overall incidence of breast cancer had fallen to 53.9:100 000. The lowest rate f...

journal_title：Maturitas

authors： Gambrell RD Jr

更新日期：1986-07-01 00:00:00

abstract：:The explanations so far proposed for the effects of oestrogens on bone metabolism in post-menopausal women have been based on the changes seen in calciotrophic hormones. However, we demonstrated in a previous study [6] that there is a decrease in the concentration of somatomedin (an insulin-like growth factor) and an ...

journal_title：Maturitas

authors： Duursma SA,Bijlsma JW,van Paassen HC,Slootweg MC

更新日期：1986-03-01 00:00:00

abstract：:From an initial group of 39, 16 cycling peri-menopausal women completed a longitudinal study in which they recorded menstrual and sexual behavior daily and were interviewed at roughly 4-mth intervals until 1 yr or more without cycling. At each interview women gave 20-ml blood samples, completed sexuality questionnaire...

journal_title：Maturitas

authors： McCoy NL,Davidson JM

更新日期：1985-09-01 00:00:00

abstract：:The aim of this chronobiological study was to investigate temporal correlations in the circadian patterns of 6 hormones, namely somatotrophic hormone (STH), prolactin (PRL), cortisol (F), aldosterone (ALD), insulin (IRI) and C-peptide (CP), assayed in systemic blood serum drawn at 07:00, 10:00, 13:00, 16:00, 19:00 and...

journal_title：Maturitas

authors： Cugini P,Lucia P,Tomassini R,Letizia C,Murano G,Scavo D,Tamburrano G,Maldonato A,Halberg F,Schramm A

更新日期：1985-07-01 00:00:00

abstract：:In a population-based prospective study it was shown that weight, height, overweight, total body size, age at first birth, parity and age at menopause are risk factors for the development of endometrial cancer. The finding that the patients had had a higher oestrogen excretion level than the controls some time before ...

journal_title：Maturitas

authors： Baanders-van Halewijn EA,Poortman J

更新日期：1985-05-01 00:00:00

abstract：:Thirty-four post-menopausal women with climacteric complaints were given conjugated equine oestrogens (1.25 mg/day) for 21 days followed by 2 days without hormones and then 5 mg medroxyprogesteroneacetate daily for 5 days. The present trial was designed to study effects on vasomotor symptoms, bleeding patterns and end...

journal_title：Maturitas

authors： Cullberg G,Knutsson F,Mattsson LA

更新日期：1984-07-01 00:00:00

abstract：:Plasma androstenedione (A) and oestrone (E1) levels were measured by radioimmunoassay in a group of 78 healthy women who had undergone a natural menopause. Of this total, 23 were symptomless (Group 1), 39 presented with a moderate climacteric syndrome (Group 2) and 16 had a severe climacteric syndrome (Group 3). The a...

journal_title：Maturitas

authors： Mango D,Scirpa P,Battaglia F,Bini E

更新日期：1984-04-01 00:00:00

abstract：:The mean plasma anion gap (Na + K + Ca + Mg)--(Cl + HCO3(-) + HPO4(2-) + protein), was significantly higher in post-menopausal women compared with pre-menopausal women (8.04 mEq/l compared with 7.03 mEq/l). This change was due, in part, to an increase in the plasma lactate concentration and to smaller increases in cit...

journal_title：Maturitas

authors： Hodgkinson A,Jones MM,Marshall RW,Skerrow SM

更新日期：1984-03-01 00:00:00

abstract：:Serum cholesterol concentrations in lipoprotein fractions and subfractions were determined in 11 peri-menopausal women both before and after bilateral oophorectomy, as well as 60 days after commencement of oral oestradiol replacement therapy. Pre-operatively, all subjects were found to have normal lipid and lipoprotei...

journal_title：Maturitas

authors： Blumenfeld Z,Aviram M,Brook GJ,Brandes JM

更新日期：1983-08-01 00:00:00

abstract：:Gynaecologists have been criticized in recent years because of their attitude towards hysterectomy; it is often stated that they are too ready to consider hysterectomy to be indicated and that hysterectomies are carried out too frequently. In order to obtain insight into the incidence of hysterectomy, 2066 women betwe...

journal_title：Maturitas

authors： van Keep PA,Wildemeersch D,Lehert P

更新日期：1983-08-01 00:00:00

abstract：:Age-related changes in the concentrations of the main plasma electrolytes and in the urinary excretion of some of these ions have been examined in 436 pre-menopausal and 117 post-menopausal women. The main changes up to the menopause were decreases in the mean plasma potassium, calcium and total protein concentrations...

journal_title：Maturitas

authors： Hodgkinson A

更新日期：1982-12-01 00:00:00

abstract：:The reduction of gonadotrophin levels, urinary calcium and hot flushes in post-menopausal patients by ethinyl oestradiol is shown to be dose dependent, near maximum response being achieved by a dose of 15 micrograms daily. Equivalent ethinyl oestradiol doses to a number of other gonadal hormone preparations have been ...

journal_title：Maturitas

authors： Jones MM,Pearlman B,Marshall DH,Crilly RG,Nordin BE

更新日期：1982-12-01 00:00:00

abstract：:A review of how the anthropologist has studied the menopause, the climacteric and middle age is given. The types of field methodology used by the anthropologist in the above-mentioned studies are described, and their application for research in other fields is suggested. Research problems which have yet to be addresse...

journal_title：Maturitas

authors： Flint M

更新日期：1982-11-01 00:00:00

abstract：:In 23 post-menopausal women, serum levels of cortisol, unconjugated dehydroepiandrosterone (DHA), dehydroepiandrosterone sulphate (DHAS), testosterone, unconjugated and total oestrone and prolactin were measured before and during an ACTH test. Significant positive correlations were found between basal levels of DHA an...

journal_title：Maturitas

authors： Brody S,Carlström K,Lagrelius A,Lunell NO,Rosenborg L

更新日期：1982-08-01 00:00:00

abstract：:By establishing a statistical profile of the average sexual behaviour of women during the climacteric period, an attempt was made to determine what influence the climacteric had on female sexual activity. With the advancement of age, the sexual activity of women tends to decline. The menopause itself tends to further ...

journal_title：Maturitas

authors： Bottiglioni F,De Aloysio D

更新日期：1982-04-01 00:00:00

abstract：:The maturation value (MV), cervical mucus parameters (ferning, Spinnbarkeit), oestrone (E1), oestradiol (E2), oestriol (E3), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), thyrotropin (TSH), growth hormone (GH), sex hormone binding globulin (SHBG), corticosteroid binding globulin (CBG) ...

journal_title：Maturitas

authors： Haspels AA,Luisi M,Kicovic PM

更新日期：1981-12-01 00:00:00

abstract：:Sex hormone binding globulin (SHBG) and pregnancy zone protein (PZP) are two highly oestrogen-inducible serum proteins. SHBG capacity and PZP level were measured in 49 women treated with three different combinations of ethinyloestradiol and norethisterone. SHBG capacity and PZP were measured before and after 6 mth of ...

journal_title：Maturitas

authors： Ottosson UB,Damber JE,Damber MG,Selstam G,Solheim F,Stigbrand T,Södergård R,von Schoultz B

更新日期：1981-12-01 00:00:00

abstract：:Five men and 8 women, 60-69 yr of age, and 4 men and 5 women, 17-37 yr of age, volunteered for this exploration of possible age-related changes in circadian-rhythm (CR) characteristics of radioimmunoassayable plasma renin (PRA) and aldosterone (PA). Blood was drawn at 06.00, 08.00, 12.00, 18.00, 20.00 and 24.00 from r...

journal_title：Maturitas

authors： Cugini P,Scavo D,Halberg F,Sothern RB,Cornelissen G,Meucci T,Salandi E,Massimiani F

更新日期：1981-08-01 00:00:00

abstract：:The possibility that the sudden discharge of thyrotropin-releasing hormone (TRH) in the brain triggers the climacteric hot flash was tested (double-blind) by an intra-venous, bolus injection of 500 microgram of TRH into 7 post-menopausal women and 1 menstruating control. Temperatures and sweating were recorded continu...

journal_title：Maturitas

authors： Molnar GW

更新日期：1981-08-01 00:00:00

abstract：:Examining such terms as climacteric or menopause and utilizing supportive historical data, an attempt is made to trace the development of these concepts, their time of inception and their spread. It is suggested that the persistence of popular terminology of the climacteric, especially in England, until late in the la...

journal_title：Maturitas

authors： Wilbush J

更新日期：1981-03-01 00:00:00

abstract：:Using the constant infusion technique we have measured the metabolic clearance rates (MCR) for delta 4-androstenedione (A), testosterone (T), oestrone (E1) and oestradiol (E2) in a large group of post-menopausal women. Their mean +/- SE age was 64.5 +/- 1.6 yr, their ages ranged from 46-90 yr. When the MCRs for each s...

journal_title：Maturitas

authors： Longcope C,Jaffee W,Griffing G

更新日期：1980-12-01 00:00:00

abstract：:The effect of estradiol valerate (Progynova, 2 mg daily) on the renin--aldosterone system was studied in nine women after bilateral oophorectomy. Plasma renin activity (PRA) and the daily urinary excretion of aldosterone (dU-Ald) were determined 4 mth after the operation -- during which no estrogen was given -- and af...

journal_title：Maturitas

authors： Punnonen R,Lammintausta R,Erkkola R,Rauramo L

更新日期：1980-07-01 00:00:00

abstract：:Serum oestrone, oestradiol and oestriol concentrations were investigated during oral treatment with oestradiol valerate and oestriol succinate in ovariectomized women. The dosages used were 1 mg oestradiol valerate in the morning and 2 mg oestriol succinate in the evening of the first day and 2 mg oestradiol valerate ...

journal_title：Maturitas

authors： Rauramo L,Punnonen R,Grönroos M

更新日期：1978-09-01 00:00:00

abstract：:The effect of two forms of exogenous estrogen and a placebo on diastolic blood pressure and bodyweight was evaluated in 50 oophorectomized women. There was no significant change in bodyweight on any form of treatment, nor was there any significant elevation in mean diastolic blood pressure. However, 2 out of 49 female...

journal_title：Maturitas

authors： Utian WH

更新日期：1978-06-01 00:00:00